Diablo 4 is almost here, and it's time to talk about the best ways to make the most out of it, get your first class up and running, and get the perfect start ahead of the true end game. This guide is based on my experience during the pre-launch playthrough and is aimed at those who want to be more efficient. Focus on the Main Story After starting up, the best thing you can do is focus on the main story and, at most, only complete the side quests already on the main path. Once you roll the credits, you unlock one of the first end-game activities you'll want to jump into right away: the Tree of Whispers . This is a solid end-game loot farm that will get you ready for the other stuff later on. The main campaign is also perfect for bringing you to level 50. Side Missions The biggest reason you'll ever want to complete side missions in the first place is for regional progress. More often than not, the XP and the rewards are given were not worth it for the time I could use for a ...